这一季对应原著小说第七部和第八部，主人公乌特雷德尝试夺回贝班堡未果，后又卷入麦西亚君位之争，并再次面对丹麦人入侵。
Combining the comedic forces of Jeff Ross and Dave Attell, and filmed at New York's Comedy Cellar, the series features zingers, audience roasts, celebrity cameos, and mic bumps.
尽管有巨额悬赏和全球搜捕，一些十恶不赦的罪犯还是逃脱了追捕。这部纪录片介绍了数名全球头号通缉犯。
Detective Inspector John Rebus is a hard drinking, unkempt, womanizing police officer whose job is his whole life. He is the most senior and most experienced DI at his station. He has a mysterious past that his partner DS Siobhan Clarke learns about from time to time through various comments Rebus makes. She is a young woman who wants to succeed, but does not have much of a personal life. She feels being paired with Rebus jeopardizes her career because of his unorthodox methods, but she is also fascinated by the man and is extremely loyal. DI Rebus' boss is Chief Superintendent Templar, a woman who was one of Rebus' lovers in a distant past. Their relationship is now one where they barely tolerate each other.
《迷失》第五季开播前就有编剧透露，将会有一名重要角色死去，而之前剧集中埋下了多重伏笔，也将会逐渐收拢，谜底慢慢揭开。这一季主要讲述“六位离岛者为什么要回去”。虽然《迷失》已经有六季完结的大框架，但是第五季的挑战也不小，在第四季那么多冲突制造完之后，剧情的节奏和爆点恐怕会有所放缓。《迷失》中依然有很多很多的谜底有待揭开，这也是剧迷一直牵挂的。和以往闪回闪前的叙事方式不同，第五季主要是岛外和岛上生活的叙事方式为主。
CW又一次一口气续订多剧，这次共13部，包括《明日传奇 DC’s Legends of Tomorrow》（S6）。
