影片讲述了自精绝古城回来后，Shirley杨带陈教授回美国治疗，却发现背上长出眼球状的红斑。胡八一与王胖子、大金牙前往陕西古蓝县进货遇到Shirley杨。四人进到一座幽灵冢险些葬于人面蜘蛛的果腹，出来后，胡八一和王胖子也长出红斑。Shirley杨拿着外公鹧鸪哨的笔记，发现黑水城的通天大佛寺中，很有可能藏有解开红斑诅咒的关键——雮尘珠。三人沿黄河继续进发，按照笔记指引进到寺内，在对抗黑玉邪神之时，发现一藏宝箱，里面究竟藏着雮尘珠，还是暗藏凶险？摸金小队又能否成功揭开鬼眼红斑的诅咒谜团呢？
17岁初中毕业便辍学在家的臭妮是个标准的问题少女，脾气暴躁，且调皮，母亲一人靠打鱼养活她。臭妮20岁这年，在一次聚会中臭妮无意中扎伤富二代陈小富。同时母亲在打鱼过程中遭鲨鱼袭击遇难，在医院抢救。在陈小富的追责中臭妮，深夜拿着父亲的照片离开小岛，踏上了寻父之路。
Mike Locken is one of the principal members of a group of freelance spies. A significant portion of their work is for the C.I.A. and while on a case for them, one of his friends turns on him and shoots him in the elbow and knee. His assignment, to protect someone, goes down in flames. He is nearly crippled, but with braces is able to again become mobile. For revenge as much as anything else, Mike goes after his ex-friend.
