DI Humphrey Goodman and the team are left stumped in the first episode of the new series when millionaire environmentalist and scientist Dan Hagen is shot on his boat while out at sea.
这部昔日的CBS旗舰剧集已经失去了一个好汉（Charlie Sheen被开除，Charlie Harper也随之死亡），现在又将失去半个好汉——因为种种原因（如果你相信CBS官方所说的「他要读大学」那你就太天真了），Angus T. Jones不再是该剧的常规演员，他的名字也将从片头字幕中彻底抹除。
制片人泰勒·谢里丹(Taylor Sheridan)将讲述大家长雅各布(Jacob Ford)和女家长卡拉(Cara Mirren)的故事，探索“20世纪初，流行病、历史性干旱、禁酒令的结束和大萧条都困扰着西部山区，而达顿一家把这里称为家。”
Detective Inspector John Rebus is a hard drinking, unkempt, womanizing police officer whose job is his whole life. He is the most senior and most experienced DI at his station. He has a mysterious past that his partner DS Siobhan Clarke learns about from time to time through various comments Rebus makes. She is a young woman who wants to succeed, but does not have much of a personal life. She feels being paired with Rebus jeopardizes her career because of his unorthodox methods, but she is also fascinated by the man and is extremely loyal. DI Rebus' boss is Chief Superintendent Templar, a woman who was one of Rebus' lovers in a distant past. Their relationship is now one where they barely tolerate each other.
Grace Devlin（乔丹娜·斯皮罗 Jordana Spiro 饰）是芝加哥罗斯福医学中心的顶级住院医师，特别擅长心肺手术。为了帮助遭到人身威胁的兄弟Nate（杰西·李·索夫 Jesse Lee Soffer 饰）还清巨额赌债，她与芝加哥南方黑帮的首领做了一个交易：私下为她曾经十分厌恶的黑帮组织成员提供医疗服务，分文不取直到还清兄弟的债。于是在白天，Grace要顶着巨大的压力仔细研究罗斯福医学中心的每一个疑难病例。然而在夜里，Grace必须调整心态去面对另一个世界，去帮助那些为非作歹之徒。
